What’s Tylenol Doing to Our Minds?

tylenol 2Tylenol isn’t addictive like narcotics, and the kids don’t take it to get high, which lends it an air of benignity and social acceptance not otherwise afforded to many pain medications. When people overdose on pills like Vicodin or Percocet, though, which contain acetaminophen, it’s that component that often does the most damage.

Acetaminophen is also more accepted in that we don’t think of Tylenol as altering our mental state. People can take it and still drive a car and go to work and remain fully present beings. But the more it’s studied, the more it seems we may be overlooking subtle cognitive effects. In 2009, research showed that it seemed to dull the pain of social rejection — sort of like alcohol or Xanax. The author of that study, Nathan DeWall at the University of Kentucky, said at that time, “Social pain, such as chronic loneliness, damages health as much as smoking and obesity.”

New research this week found that Tylenol altered the way subjects passed moral judgements. Psychologists used that as a proxy measure for personal distress, a relationship that has been previously demonstrated.

Daniel Randles and colleagues at the University of British Columbia write in the journal Psychological Science, “The meaning-maintenance model posits that any violation of expectations leads to an affective experience that motivates compensatory affirmation. We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen.” Totally.

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